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College Football Week 6 Picks: Top Betting Odds for Saturday's Late Games

The USC Trojans' biggest Week 6 opponent may be themselves.

Lincoln Riley's team needs to keep its focus on Saturday night against the Arizona Wildcats instead of looking ahead to the massive Week 7 showdown with the Notre Dame Fighting Irish.

USC also needs to clear out the emotions from the high-scoring win over the Colorado Buffaloes last weekend in Boulder.

Some college football bettors may think Saturday presents the perfect storm of circumstances to fade USC on the point spread, but the Trojans have been elite at home and can exploit Arizona's biggest defensive weakness with Caleb Williams.